Journal article

Hemagglutination inhibiting antibodies and protection against seasonal and pandemic influenza infection

Annette Fox, Quynh Mai Le, Thi Thanh Le, Marcel Wolbers, Le Khanh Hang Nguyen, Quang Thai Pham, Thi Thu Yen Nguyen, Nguyen Minh Hoa Le, Juliet E Bryant, Nhu Duong Tran, Dinh Thoang Dang, Ian G Barr, Heiman Wertheim, Jeremy Farrar, Tran Hien Nguyen, Peter Horby

JOURNAL OF INFECTION | W B SAUNDERS CO LTD | Published : 2015

Abstract

OBJECTIVES: Hemagglutination inhibiting (HI) antibodies correlate with influenza vaccine protection but their association with protection induced by natural infection has received less attention and was studied here. METHODS: 940 people from 270 unvaccinated households participated in active ILI surveillance spanning 3 influenza seasons. At least 494 provided paired blood samples spanning each season. Influenza infection was confirmed by RT-PCR on nose/throat swabs or serum HI assay conversion. RESULTS: Pre-season homologous HI titer was associated with a significantly reduced risk of infection for H3N2 (OR 0.61, 95%CI 0.44-0.84) and B (0.65, 95%CI 0.54-0.80) strains, but not H1N1 strains, w..

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