Journal article

Comparative Evaluation of Silicone Hydrogel Contact Lenses and Autologous Serum for Management of Sjogren Syndrome-Associated Dry Eye

Jinyang Li, Xiahua Zhang, Qinxiang Zheng, Yirui Zhu, Hui Wang, Huixiang Ma, Vishal Jhanji, Wei Chen

CORNEA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

PURPOSE: To comparatively evaluate the efficacy of a bandage contact lens (BCL) and autologous serum (AS) eye drops in the management of severe dry eye caused by Sjögren syndrome (SS). METHODS: In this prospective randomized study, 40 patients with SS were enrolled. Patients were divided into 2 treatment groups: BCL and AS. RESULTS: A total of 37 patients were included, 18 patients (35 eyes) in the AS group and 19 patients (36 eyes) in the BCL group. At the end of 6 weeks, the best-corrected visual acuity improved significantly in the BCL group (0.5 ± 0.3 vs. 0.3 ± 0.2, P = 0.003) but not in the AS group (0.4 ± 0.3 vs. 0.3 ± 0.3, P = 0.11). The best-corrected visual acuity remained stable up..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by Wenzhou Science and Technology Bureau


Funding Acknowledgements

Supported by research Grants 81170820 and 81470605 from National Natural Science Foundation of China; research Grant Y20140368 from Wenzhou Science and Technology Bureau. The sponsor or funding organization had no role in the design or conduct of this research.