Journal article
The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis
Josiah Ochieng, Gladys N Nangami, Olugbemiga Ogunkua, Isabelle R Miousse, Igor Koturbash, Valerie Odero-Marah, Lisa McCawley, Pratima Nangia-Makker, Nuzhat Ahmed, Yunus Luqmani, Zhenbang Chen, Silvana Papagerakis, Gregory T Wolf, Chenfang Dong, Binhua P Zhou, Dustin G Brown, Annamaria Colacci, Roslida A Hamid, Chiara Mondello, Jayadev Raju Show all
Carcinogenesis | OXFORD UNIV PRESS | Published : 2015
Abstract
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of low-dose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial-mesenchymal transition, for example..
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Awarded by National Institute of Environmental Health Sciences
Awarded by National Institute on Minority Health and Health Disparities-NIMHD
Awarded by Fondazione Cariplo
Awarded by Kuwait Institute for the Advancement of Sciences
Awarded by Grant University Scheme (RUGS) Ministry of Education Malaysia
Awarded by Italian Ministry of University and Research
Awarded by US Public Health Service
Awarded by Department of Science and Technology, Government of India
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Awarded by National Institute on Minority Health and Health Disparities
Funding Acknowledgements
National Institute of Environmental Health Sciences (R13ES023276); National Institute on Minority Health and Health Disparities-NIMHD (G12 MD007586 to J.O.), Fondazione Cariplo (2011-0370 to C.M.), Kuwait Institute for the Advancement of Sciences (2011-1302-06 to F.al-M), Grant University Scheme (RUGS) Ministry of Education Malaysia (04-02-12-2099RU to R.A.H), Italian Ministry of University and Research (2009FZZ4XM_002 to A.A.), The University of Florence (ex60%2012 to A.A.), US Public Health Service Grants (R01 CA92306, R01 CA92306-51, R01 CA113447 to R.R.), Department of Science and Technology, Government of India (SR/FT/LS-063/2008 to N.S.).