Journal article

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Josiah Ochieng, Gladys N Nangami, Olugbemiga Ogunkua, Isabelle R Miousse, Igor Koturbash, Valerie Odero-Marah, Lisa McCawley, Pratima Nangia-Makker, Nuzhat Ahmed, Yunus Luqmani, Zhenbang Chen, Silvana Papagerakis, Gregory T Wolf, Chenfang Dong, Binhua P Zhou, Dustin G Brown, Annamaria Colacci, Roslida A Hamid, Chiara Mondello, Jayadev Raju Show all

Carcinogenesis | OXFORD UNIV PRESS | Published : 2015

Abstract

The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of low-dose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial-mesenchymal transition, for example..

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Grants

Awarded by National Institute of Environmental Health Sciences


Awarded by National Institute on Minority Health and Health Disparities-NIMHD


Awarded by Fondazione Cariplo


Awarded by Kuwait Institute for the Advancement of Sciences


Awarded by Grant University Scheme (RUGS) Ministry of Education Malaysia


Awarded by Italian Ministry of University and Research


Awarded by US Public Health Service


Awarded by Department of Science and Technology, Government of India


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Awarded by National Institute on Minority Health and Health Disparities


Funding Acknowledgements

National Institute of Environmental Health Sciences (R13ES023276); National Institute on Minority Health and Health Disparities-NIMHD (G12 MD007586 to J.O.), Fondazione Cariplo (2011-0370 to C.M.), Kuwait Institute for the Advancement of Sciences (2011-1302-06 to F.al-M), Grant University Scheme (RUGS) Ministry of Education Malaysia (04-02-12-2099RU to R.A.H), Italian Ministry of University and Research (2009FZZ4XM_002 to A.A.), The University of Florence (ex60%2012 to A.A.), US Public Health Service Grants (R01 CA92306, R01 CA92306-51, R01 CA113447 to R.R.), Department of Science and Technology, Government of India (SR/FT/LS-063/2008 to N.S.).