Journal article

Reducing the impact of influenza-associated secondary pneumococcal infections

Edin J Mifsud, Amabel C Tan, Kirsty R Short, Lorena E Brown, Brendon Y Chua, David C Jackson



When administered prophylactically, we show that the Toll-like receptor-2 (TLR-2) agonist PEG-Pam2Cys (pegylated-S-(2,3-bis(palmitoyloxy)propyl)cysteine) not only mediates potent anti-viral activity against influenza virus but also reduces the impact of secondary infections with Streptococcus pneumoniae (the pneumococcus) by reducing (i) pulmonary viral and bacterial burdens, (ii) the levels of proinflammatory cytokines that normally accompany influenza and S. pneumoniae secondary infections and (iii) the vascular permeability of the pulmonary tract that can allow bacterial invasion of the blood in mice. We also show that an inactivated detergent-disrupted influenza virus vaccine formulated ..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by funding from Program Grants APP1071916 and 567122 and Project Grant APP1063209 from the National Health and Medical Research Council of Australia. DCJ is supported by a Research Fellowship from the NH&MRC. We thank Ms Emily Fairmaid, Ms Chinn Yi Wong and Ms Kylie Horrocks for technical assistance and Dr Steve Rockman for providing reagents.