Journal article
Cerebrovascular pressure reactivity in children with traumatic brain injury
PM Lewis, M Czosnyka, BG Carter, JV Rosenfeld, E Paul, N Singhal, W Butt
Pediatric Critical Care Medicine | Published : 2015
Abstract
Objective: Traumatic brain injury is a significant cause of morbidity and mortality in children. Cerebral autoregulation disturbance after traumatic brain injury is associated with worse outcome. Pressure reactivity is a fundamental component of cerebral autoregulation that can be estimated using the pressure-reactivity index, a correlation between slow arterial blood pressure, and intracranial pressure fluctuations. Pressure-reactivity index has shown prognostic value in adult traumatic brain injury, with one study confirming this in children. Pressure-reactivity index can identify a cerebral perfusion pressure range within which pressure reactivity is optimal. An increasing difference betw..
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Awarded by Medical Research Council
Funding Acknowledgements
Supported, in part, by the Transport Accident Commission.Dr. Lewis has a financial interest in a fraction of the licensing fee of ICM+ Tools. Dr. Czosnyka was supported by the National Institute of Health Research, UK, Biomedical Research Center (Neuroscience Theme) and has a financial interest in a fraction of the licensing fee of ICM+. ICM+ (http://www.neurosurg.cam.ac.uk/icmplus) is licensed by Cambridge Enterprise (Cambridge, United Kingdom). ICM+ Tools (http://www.med.monash.edu.au/surgery/alfred/services/icm.html) is licensed by Monash University. Dr. Lewis disclosed royalties (Software only recently licensed, royalties to Dr. Lewis and his institution not received yet. ICM+ Tools is licensed by Monash University. As its developer, Dr. Lewis has a financial interest in a small part of the licensing fee). Dr. Czosnyka received grant support from the National Institute of Health Research, UK; consulted for J&J Codman; is employed by the University of Cambridge; lectured for Integra LifeScience; and received royalties from Cambridge Enterprise Ltd. Dr. Carter's institution received grant support from TAC. The remaining authors have disclosed that they do not have any potential conflicts of interest.