Journal article

An arterially perfused nose-olfactory bulb preparation of the rat

Fernando Perez de los Cobos Pallares, Davor Stanic, David Farmer, Mathias Dutschmann, Veronica Egger



A main feature of the mammalian olfactory bulb network is the presence of various rhythmic activities, in particular, gamma, beta, and theta oscillations, with the latter coupled to the respiratory rhythm. Interactions between those oscillations as well as the spatial distribution of network activation are likely to determine olfactory coding. Here, we describe a novel semi-intact perfused nose-olfactory bulb-brain stem preparation in rats with both a preserved olfactory epithelium and brain stem, which could be particularly suitable for the study of oscillatory activity and spatial odor mapping within the olfactory bulb, in particular, in hitherto inaccessible locations. In the perfused olf..

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Awarded by German Research Foundation (DFG)-Collaborative Research Centres (SFB)

Funding Acknowledgements

This work was funded by German Research Foundation (DFG)-Collaborative Research Centres (SFB) 870 (F. Perez de los Cobos Pallares and V. Egger), Bayerische Forschungsallianz (BayForIntAn; V. Egger), Experimental and Clinical Neurosciences (ECN)-Elite Network of Bavaria (ENB; F. Perez de los Cobos Pallares and V. Egger), an Australian Research Council Future Fellowship (M. Dutschmann), and the Florey Institute of Neuroscience and Mental Health (D. Stanic, D. Farmer, and M. Dutschmann). We also acknowledge the support of the Victorian Government through the Operational Infrastructure Scheme.