Journal article
Colorectal cancer through simulation and experiment
SK Kershaw, HM Byrne, DJ Gavaghan, JM Osborne
Iet Systems Biology | INST ENGINEERING TECHNOLOGY-IET | Published : 2013
Abstract
Colorectal cancer (CRC) has formed a canonical example of tumourigenesis ever since its use in Fearon and Vogelstein's linear model of genetic mutation, and continues to generate a huge amount of research interest. Over time, the field has witnessed a transition from solely experimental work to the inclusion of mathematical and computational modelling. The fusion of these disciplines has the potential to provide valuable insights into oncologic processes, but also presents the challenge of uniting many diverse perspectives. Furthermore, the cancer cell phenotype defined by the 'Hallmarks of Cancer' has been extended in recent times and provides an excellent basis for future research. The aut..
View full abstractGrants
Awarded by King Abdullah University of Science and Technology (KAUST)
Awarded by DJG through the OCISB project
Awarded by Systems Biology Doctoral Training Centre
Awarded by Systems Approaches to Biomedical Science Industrial Doctorate Centre
Funding Acknowledgements
SKK is supported by an EPSRC-funded Systems Biology Doctoral Training Centre studentship and a Google Europe Scholarship. HMB: This publication was based on work supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). DJG is funded through the OCISB project (BB/D020190/1) and the Systems Biology Doctoral Training Centre (EP/G50029/1). JMO is supported by Microsoft Research UK and the Life Sciences Interface and Systems Biology Doctoral Training Centres, and the Systems Approaches to Biomedical Science Industrial Doctorate Centre (EP/E501605/1, EP/G50029/1 and EP/G037280/1, respectively).