Journal article

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Katarina Marcinko, Adam L Bujak, James SV Lally, Rebecca J Ford, Tammy H Wong, Brennan K Smith, Bruce E Kemp, Yonchu Jenkins, Wei Li, Todd M Kinsella, Yasumichi Hitoshi, Gregory R Steinberg

Molecular Metabolism | ELSEVIER SCIENCE BV | Published : 2015

DOI: 10.1016/j.molmet.2015.06.002

University of Melbourne Researchers

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Keywords

R419
Obesity
Glut4
Wt, Wildtype
Ct, Computed Tomography
Glucose-Uptake
Phosphorylation
Mitochondrial
Aicar, 5-Aminoimidazole-4-Carboxamide-1-Β-D-Ribofuranoside
Science & Technology
Ta, Tibialis Anterior
Exercise-Mimetic
Gir, Glucose Infusion Rate
Gdr, Glucose Disposal Rate
Oxphos, Proteins Involved in Oxidative Phosphorylation (electron Transport Chain)
Ampk, Amp-Activated Protein Kinase
Acc, Acetyl-Coa Carboxylase
Edl, Extensor Digitorum Longus
R419, N-(1-(4-Cyanobenzyl) Piperidin-4-Yl)-6-(4-(4-Methoxybenzoyl) Piperidine-1-Carbonyl
Metformin
Auc, Area Under the Curve
Resistance
Glut4, Glucose Transporter 4
Cox, Cytochrome C Oxidase
Null Mice
Endocrinology & Metabolism
Life Sciences & Biomedicine
Cells
Hfd, High-Fat Diet (45% Kcal Fat)
Hgo, Hepatic Glucose Output
Ampk
Diabetes
Ampk-Mko, Skeletal Muscle-Specific Ampk Β1β2 Floxed Cre-
Complex-I
Protein-Kinase Ampk
Independent Pathways
Mitochondrial Biogenesis
2-Dg, 2-Deoxyglucose
Tbp, Tata-Binding Protein