A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus
Sarah Preston, Abdul Jabbar, Robin B Gasser
INFECTION GENETICS AND EVOLUTION | ELSEVIER SCIENCE BV | Published : 2016
High-throughput molecular and computer technologies have become instrumental for systems biological explorations of parasites. Investigating the genomes and transcriptomes of different developmental stages of parasitic nematodes can provide insights into gene expression, regulation and function in the parasite, which is a significant step toward understanding their biology as well as host interactions and disease. This article covers aspects of a talk given at the MEEGID XII conference in Thailand in 2014. Here, we refer to recent studies of the genomes and transcriptomes of socioeconomically important parasitic nematodes of animals; provide an account of the barber's pole worm (Haemonchus c..View full abstract
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Awarded by Victorian Life Sciences Computation Initiative on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government
Funding from the Australian Research Council, National Health and Medical Research Council (NHMRC) is gratefully acknowledged (RBG) as is support from the Victorian Life Sciences Computation Initiative (Grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. Other support from the Australian Academy of Science, the Australian-American Fulbright Commission, Alexander von Humboldt Foundation and Melbourne Water Corporation is gratefully acknowledged. RBG thanks all current and past Lab members, and numerous collaborators for their contributions over the years.