Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Fredrick R Schumacher, Stephanie L Schmit, Shuo Jiao, Christopher K Edlund, Hansong Wang, Ben Zhang, Li Hsu, Shu-Chen Huang, Christopher P Fischer, John F Harju, Gregory E Idos, Flavio Lejbkowicz, Frank J Manion, Kevin McDonnell, Caroline E McNeil, Marilena Melas, Hedy S Rennert, Wei Shi, Duncan C Thomas, David J Van Den Berg Show all
Nature Communications | NATURE PUBLISHING GROUP | Published : 2015
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Awarded by National Cancer Institute, National Institutes of Health under RFA
CORECT: this work was supported by the National Cancer Institute, National Institutes of Health under RFA # CA-09-002, NIH/NCI U19 CA148107. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the CORECT consortium, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the CORECT Consortium. ASTERISK: we are very grateful to Dr Bruno Buecher without whom this project would not have existed. We also thank all those who agreed to participate in this study, including the patients and the healthy control persons, as well as all the physicians, technicians and students. DACHS: we thank all participants and cooperating clinicians, and Ute Handte-Daub, Renate Hettler-Jensen, Utz Benscheid, Muhabbet Celik and Ursula Eilber for excellent technical assistance. GECCO: we thank all those at the GECCO Coordinating Center for helping bring together the data and people that made this project possible. HPFS, NHS and PHS: we acknowledge Patrice Soule and Hardeep Ranu of the Dana-Farber Harvard Cancer Center High-Throughput Polymorphism Core who assisted in the genotyping for NHS, HPFS and PHS under the supervision of Dr Immaculata Devivo and Dr David Hunter, Qin (Carolyn) Guo and Lixue Zhu who assisted in programming for NHS and HPFS and Haiyan Zhang who assisted in programming for the PHS. We thank the participants and staff of the Nurses' Health Study and the Health Professionals Follow-Up Study, for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. In addition, this study was approved by the Connecticut Department of Public Health (DPH) Human Investigations Committee. Certain data used in this publication were obtained from the DPH. We assume full responsibility for analyses and interpretation of these data. PLCO: we thank Drs Christine Berg and Philip Prorok, Division of Cancer Prevention, National Cancer Institute, the Screening Center investigators and staff or the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, Mr. Tom Riley and staff, Information Management Services Inc., Ms Barbara O'Brien and staff, Westat Inc. and Drs Bill Kopp, Wen Shao and staff, SAIC-Frederick. Most importantly, we acknowledge the study participants for their contributions for making this study possible. The statements contained herein are solely those of the authors and do not represent or imply concurrence or endorsement by NCI. PMH: we thank the study participants and staff of the Hormones and Colon Cancer study. WHI: we thank the WHI investigators and staff for their dedication, and the study participants for making the program possible. A full listing of WHI investigators can be found at https://cleo.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Short%20List.pdf. ACC: we thank all study participants and research staff of all studies for their contributions and commitment to this project, Regina Courtney for DNA preparation and Jing He for data processing.