Successive Generations in a Rat Model Respond Differently to a Constant Obesogenic Environment
Alice H Tait, David Raubenheimer, Mark P Green, Cinda L Cupido, Peter D Gluckman, Mark H Vickers
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
Research has shown that if a mother experiences a transitory perturbation to her environment during pregnancy or lactation, there are transgenerational consequences often involving a disordered metabolic phenotype in first generation offspring with recovery across subsequent generations. In contrast, little is known about the nature of the transgenerational response of offspring when a mother experiences a perturbation that is not transitory but instead persists across generations. Our study, using a rat model, subjected the parental generation to a change in environment and concomitant shift from a grain-based to obesogenic diets to generate an adipose phenotype in first generation offsprin..View full abstract
Awarded by Health Research Council of New Zealand
Funding was provided by the Health Research Council of New Zealand, Project 05/244 (http://www.hrc.govt.nz/) Public good funding. The authors also acknowledge funding support from Gravida: National Centre for Growth and Development, the Tertiary Education Commission of New Zealand and the Maurice Paykel Research Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.