Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

AY Robin; K Krishna Kumar; D Westphal; AZ Wardak; GV Thompson; G Dewson; PM Colman; PE Czabotar

Journal article

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

AY Robin, K Krishna Kumar, D Westphal, AZ Wardak, GV Thompson, G Dewson, PM Colman, PE Czabotar

Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2015

DOI: 10.1038/cddis.2015.141

University of Melbourne Researchers

Peter Czabotar Author Medical Biology (W.E.H.I.)

Adeline Robin Author Medical Biology (W.E.H.I.)

Grant Dewson Author Medical Biology (W.E.H.I.)

Peter Colman Author Medical Biology (W.E.H.I.)

Grants

Awarded by NHMRC (Australia)

Funding Acknowledgements

We thank Ruth Kluck and Jerry Adams for discussions and comments on the manuscript and the beamline staff at the Australian Synchrotron where diffraction data were collected. Crystallisation experiments were performed at the Bio21 C3 Collaborative Crystallisation Centre. PEC and PMC acknowledge NHMRC Fellowships, GD acknowledges an ARC Future Fellowship and DW acknowledges a DFG Postdoctoral Fellowship. Our work is supported by the NHMRC (Australia; Projects Grants 1079706, 1059331 and 1023055 and Program Grant 1016701), the Australian Cancer Research Foundation, the Leukemia and Lymphoma Society (US), the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIISS.