The Impact of Diabetes on Brain Function in Childhood and Adolescence
Fergus J Cameron
PEDIATRIC CLINICS OF NORTH AMERICA | W B SAUNDERS CO-ELSEVIER INC | Published : 2015
A constant supply of glucose to the brain is critical for normal cerebral metabolism. The dysglycemia of type 1 diabetes (T1D) can affect activity, survival, and function of neural cells. Clinical studies in T1D have shown impairments in brain morphology and function. The most neurotoxic milieu seems to be young age and/or diabetic ketoacidosis at onset, severe hypoglycemia under the age of 6 years followed by chronic hyperglycemia. Adverse cognitive outcomes seem to be associated with poorer mental health outcomes. It is imperative to improve outcomes by investigating the mechanisms of injury so that neuroprotective strategies independent of glycemia can be identified.
The author has received research support, travel support and honoraria from Novo Nordisk, Lilly, Medtronic, Roche, Abbott, The Juvenile Diabetes Research Foundation and the National Health & Medical Research Council of Australia.