Journal article

BAFF-driven autoimmunity requires CD19 expression

Kirsten A Fairfax, Evelyn Tsantikos, William A Figgett, Fabien B Vincent, Pin Shie Quah, Melanie LePage, Margaret L Hibbs, Fabienne Mackay

JOURNAL OF AUTOIMMUNITY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2015

Abstract

B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that resembles systemic lupus erythematosus (SLE) in a T cell-independent but MyD88-dependent manner, implicating toll-like receptor (TLR) signaling. The specific B cell subtypes that make pro-inflammatory autoantibodies in BAFF-Tg mice are TLR-activated innate B cells known as marginal zone (MZ) and B1 B cells. These cells infiltrate the salivary glands and kidneys of diseased BAFF-Tg mice. However, loss of B1a or MZ B cells does not protect BAFF-Tg mice against disease, suggesting that B1b B cells might be t..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

We thank the facilities of our respective institutes, particularly those responsible for animal husbandry, flow cytometry, and imaging. Thanks also goes to Cameron Wells for help with graphics. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. This work was supported by the National Health and Medical Research Council, Australia (GNT1008520) (Program Grant 1016953, Fellowship 516786, 1020630 and 603124). The authors have no competing interests.