Journal article
The histopathology of polymicrogyria: A series of 71 brain autopsy studies
AC Jansen, Y Robitaille, M Honavar, N Mullatti, RJ Leventer, E Andermann, F Andermann, W Squier
Developmental Medicine and Child Neurology | WILEY | Published : 2016
DOI: 10.1111/dmcn.12840
Abstract
Aim: Polymicrogyria (PMG) is one of the most common forms of cortical malformation yet the mechanism of its development remains unknown. This study describes the histopathological aspects of PMG in a large series including a significant proportion of fetal cases. Method: We have reviewed the neuropathology and medical records of 44 fetuses and 27 children and adults in whom the cortical architecture was focally or diffusely replaced by one or more festooning bands of neurons. Results: The pial surface of the brain overlying the polymicrogyric cortex was abnormal in almost 90% of cases irrespective of the aetiology. This accords with animal studies indicating the importance of the leptomening..
View full abstractGrants
Awarded by Medical Research Council
Funding Acknowledgements
We are grateful to the parents who have allowed us to examine and study their infants' brains. ACJ has received funding from the Scientific Fund Willy Gepts. The authors have stated they had no interests that might be perceived as posing a conflict or bias.