Journal article
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
Sudarshini Ramanathan, Kristina Prelog, Elizabeth H Barnes, Esther M Tantsis, Stephen W Reddel, Andrew PD Henderson, Steve Vucic, Mark P Gorman, Leslie A Benson, Gulay Alper, Catherine J Riney, Michael Barnett, John DE Parratt, Todd A Hardy, Richard J Leventer, Vera Merheb, Margherita Nosadini, Victor SC Fung, Fabienne Brilot, Russell C Dale
MULTIPLE SCLEROSIS JOURNAL | SAGE PUBLICATIONS LTD | Published : 2016
Abstract
BACKGROUND: Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes. OBJECTIVE: We aimed to define radiological features of first-episode demyelinating ON. METHODS: We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON (n=7). RESULTS: Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal inv..
View full abstractGrants
Awarded by Multiple Sclerosis Research Australia
Funding Acknowledgements
This work was supported by Multiple Sclerosis Research Australia [grant number 14-021], the Trish MS Research Foundation, the Star Scientific Foundation (Australia), MS Angels Melbourne (Australia), the Petre Foundation (Australia), and the National Health and Medical Research Council (Australia). This study was initiated and performed by the investigators, and the funding sources as listed above did not have any role in the design, conduct or data management of the study, nor writing of the report.