Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

Grants

Funding Acknowledgements

We thank Dr Francisco Javier Gamo and Dr Jose Maria Bueno-Calderon (GlaxoSmithKline, Tres Cantos facility, Spain) for the provision of modified azalides. Prof. Alan Cowman, The Walter & Eliza Hall Institute, for advice and support throughout the study. Human erythrocytes were kindly provided by the Red Cross Blood Bank (Melbourne, Australia). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council (NHMRC) Independent Medical Research Institutes Infrastructure Support Scheme (IRIISS). Funding for the research came from the NHMRC of Australia (program grant 637406 to BSC, GIM and JGB) and a Career Development Award to JGB; Peter Doherty Australian Biomedical Fellowship to DWW (APP1035715); postgraduate research scholarship to FA (APP1055246), the Australian Research Council (Future Fellowship to JGB (FT0992317); JB (FT100100112)) and the Australian Cancer Research Foundation. JB is currently supported by a new Investigator Award from the Wellcome Trust (100993/Z/13/Z). GIM is a Howard Hughes International Scholar. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have declared that no conflict of interest exists.