The effect of urinary and arterial blood pH on the progression of acute kidney injury in critically ill patients with systemic inflammatory response syndrome or sepsis and oliguria

Abstract

PURPOSE: The aim of this study was to examine the relationship between urinary and arterial blood pH and the progression of acute kidney injury in critically ill patients with sepsis or SIRS and oliguria. DESIGN AND SETTING: A prospective observational study was performed on critically ill adults in a tertiary intensive care unit in Melbourne, Australia. Urinary and arterial blood pH were measured at 12 hourly intervals for 60h for patients with sepsis or SIRS, oliguria and who were at high risk of acute kidney injury. Patient RIFLE class at baseline and 60h were assessed for an association to urinary and arterial blood pH. Secondarily, change in peak serum creatinine from baseline over 5 da..