YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

FC Brownfoot; S Tong; NJ Hannan; R Hastie; P Cannon; L Tuohey; TJ Kaitu'u-Lino

Journal article

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

FC Brownfoot, S Tong, NJ Hannan, R Hastie, P Cannon, L Tuohey, TJ Kaitu'u-Lino

Molecular and Cellular Endocrinology | Published : 2015

DOI: 10.1016/j.mce.2015.06.033

Abstract

Preeclampsia is a serious complication of pregnancy with no medical treatment. It is caused by intermittent placental hypoxia and release of sFlt-1 and soluble endoglin, leading to wide spread maternal endothelial dysfunction and multisystem organ injury. YC-1 is a guanylyl cyclase activator and HIF1. α inhibitor developed for use in hypertension and atherosclerosis. We examined whether YC-1 reduces sFlt-1 and sENG secretion and reverses endothelial dysfunction in primary human tissues. YC-1 significantly reduced sFlt-1 and sENG secretion from human umbilical vein endothelial cells, purified primary trophoblast cells and placental explants taken from patients with preterm preeclampsia. This ..

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University of Melbourne Researchers

Fiona Brownfoot Author

Stephen Tong Author

Natalie Hannan Author

Ping Cannon Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by The National Health and Medical Research Council of Australia (NHMRC; #1048707, #1046484) and an Arthur Wilson RANZCOG scholarship. FB was supported by an Australian Postgraduate Award and an AVANT scholarship. The NHMRC provided salary support (#1050765 to ST #1062418 to TKL, #628927 to NJH). The funders had no role in study design, data collection, analysis, decision to publish or helped to prepare the manuscript.