Prospects for antibody-based universal influenza vaccines in the context of widespread pre-existing immunity
Adam Kenneth Wheatley, Stephen John Kent
EXPERT REVIEW OF VACCINES | TAYLOR & FRANCIS LTD | Published : 2015
Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates global influenza surveillance efforts, frequent vaccine reformulation and annual readministration. There is, therefore, tremendous interest in the development of novel strategies to elicit broad and durable protection against both seasonal and pandemic infection. This review presents an overview of candidate universal influenza vaccines designed to elicit cross-protective antibody ..View full abstract
AK Wheatley is supported by funding from the Australian Research Council. SJ Kent is supported by funding from the National Health and Medical Research Council of Australia. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.