Journal article

Capsosomes as Long-Term Delivery Vehicles for Protein Therapeutics.

JW Maina, JJ Richardson, R Chandrawati, K Kempe, MP van Koeverden, F Caruso

Langmuir: the ACS journal of surfaces and colloids | American Chemical Society | Published : 2015

Abstract

We report the preparation of polymer capsules containing liposomal subcompartments, termed capsosomes, and their ability for the sustained delivery of protein therapeutics. Capsosomes were formed through the layer-by-layer (LbL) assembly of polymers and protein-loaded liposomes, followed by the formation of a capsule membrane based on disulfide cross-linked poly(methacrylic acid). The loading capacities of a model cargo (lysozyme) and brain-derived neurotrophic factor (BDNF), an important neurotrophin that has significant physiological functions on the nervous system, were determined, and the long-term release kinetics of the proteins was investigated in simulated physiological conditions. T..

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Grants

Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC under the Australian Laureate Fellowship scheme


Funding Acknowledgements

This research was conducted and funded by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project CE140100036) and the ARC under the Australian Laureate Fellowship (FL120100030) scheme. Kristian Kempe is grateful to the Alexander von Humboldt Foundation for a Feodor Lynen Research Fellowship.