Exploring the Benefits of Molecular Testing for Gonorrhoea Antibiotic Resistance Surveillance in Remote Settings
Ben B Hui, Nathan Ryder, Jiunn-Yih Su, James Ward, Marcus Y Chen, Basil Donovan, Christopher K Fairley, Rebecca J Guy, Monica M Lahra, Mathew G Law, David M Whiley, David G Regan
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015
BACKGROUND: Surveillance for gonorrhoea antimicrobial resistance (AMR) is compromised by a move away from culture-based testing in favour of more convenient nucleic acid amplification test (NAAT) tests. We assessed the potential benefit of a molecular resistance test in terms of the timeliness of detection of gonorrhoea AMR. METHODS AND FINDINGS: An individual-based mathematical model was developed to describe the transmission of gonorrhoea in a remote Indigenous population in Australia. We estimated the impact of the molecular test on the time delay between first importation and the first confirmation that the prevalence of gonorrhoea AMR (resistance proportion) has breached the WHO-recomme..View full abstract
Awarded by National Health and Medical Research Council
This work was supported by National Health and Medical Research Council Project Grants (APP1025517). The Kirby Institute is funded by the Australian Government Department of Health and Ageing and is affiliated with the Faculty of Medicine, University of New South Wales. The views expressed in this publication do not necessarily represent the position of the Australian Government.