Journal article

14-3-3 zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders

Xiangjun Xu, Emily J Jaehne, Zarina Greenberg, Peter McCarthy, Eiman Saleh, Clare L Parish, Daria Camera, Julian Heng, Matilda Haas, Bernhard T Baune, Udani Ratnayake, Maarten van den Buuse, Angel F Lopez, Hayley S Ramshaw, Quenten Schwarz

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2015

Abstract

Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we recently found that 14-3-3ζ(-/-) mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play a significant role in disease pathogenesis we generated a new congenic strain in the BALB/c background to determine the impact of genetic interactions on the 14-3-3ζ(-/-) phenotype. In addition to replicating defects such as aberrant mossy fibre connectivity and impaired spatial memory, our analysis of 14-3-3ζ(-/-) BALB/c mice identified enlarged lateral ventricles, reduced synaptic density a..

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Grants

Funding Acknowledgements

We thank Rebecca Wright and Melanie Pudney for genotyping mice and SA Pathology ACF staff maintaining the mouse colonies. This work was funded by grants from the National Health and Medical Research Council of Australia and Medvet Laboratories. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant. HR is the recipient of the Peter Nelson Leukaemia Research Fellowship. CLP was supported by a Senior Medical Research Fellowship provided by the Viertel Charitable Foundation, Australia.