Journal article
Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene
KP Burdon, RD Fogarty, W Shen, S Abhary, G Kaidonis, B Appukuttan, AW Hewitt, S Sharma, M Daniell, RW Essex, JH Chang, S Klebe, SR Lake, B Pal, A Jenkins, G Govindarjan, P Sundaresan, EL Lamoureux, K Ramasamy, M Pefkianaki Show all
Diabetologia | Published : 2015
Abstract
Aims/hypothesis: Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sight-threatening diabetic retinopathy using a genome-wide association study. Methods: Retinopathy was assessed in white Australians with type 2 diabetes mellitus. Genome-wide association analysis was conducted for comparison of cases of sight-threatening diabetic retinopathy (n = 336) with diabetic controls with no retinopathy (n = 508). Top ranking single nucleotide polymorphis..
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Awarded by National Institute for Health Research
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia [no. 595918] and the Ophthalmic Research Institute of Australia. KPB is supported by a Senior Research Fellowship from the NHMRC and JEC by a Practitioner Fellowship from the NHMRC. Research conducted at Moorfields Eye Hospital was funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust (www.nihr.ac.uk) and the University College, London Institute of Ophthalmology. Research at the Centre for Eye Research Australia was funded by the Australian Research Council (www.arc.gov.au) grant LP0884108.