Journal article
Antiepileptic drugs and intrauterine death
T Tomson, D Battino, E Bonizzoni, JJ Craig, D Lindhout, E Perucca, A Sabers, SV Thomas, F Vajda
Neurology | Published : 2015
Abstract
Objective: To compare the risk of spontaneous abortions and stillbirth associated with maternal use of different antiepileptic drugs (AEDs). Methods: The EURAP registry is an observational international cohort study primarily designed to determine the risk of major congenital malformations (MCMs) after prenatal AED exposure. Using EURAP data, we prospectively monitored pregnancies exposed to the 6 most common AED monotherapies and to polytherapy. Intrauterine death (spontaneous abortion and stillbirth combined) was the primary endpoint. Results: Of 7,055 pregnancies exposed to monotherapy with lamotrigine (n 1,910), carbamazepine (n 1,713), valproic acid (n 1,171), levetiracetam (n 324), oxc..
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Awarded by Netherlands Epilepsy Foundation (NEF)
Funding Acknowledgements
EURAP has received financial support from the pharmaceutical companies Bial, Eisai, GlaxoSmithKline, Janssen-Cilag, Novartis, Pfizer, Sanofi-Aventis, and UCB, from Netherlands Epilepsy Foundation (NEF) grant 03-18 (Lindhout), and from Stockholm County Council, ALF (Tomson). The sponsors had no influence on the conduct of the study, analysis, interpretation, writing of the manuscript, or the decision to publish the results.