Journal article

Pubertal induction in hypogonadism: Current approaches including use of gonadotrophins

Margaret Zacharin

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | ELSEVIER SCI LTD | Published : 2015

Abstract

Primary disorders of the gonad or those secondary to abnormalities of the hypothalamic pituitary axis result in hypogonadism. The range of health problems of childhood and adolescence that affect this axis has increased, as most children now survive chronic illness, but many have persisting deficits in gonadal function as a result of their underlying condition or its treatment. An integrated approach to hormone replacement is needed to optimize adult hormonal and bone health, and to offer opportunities for fertility induction and preservation that were not considered possible in the past. Timing of presentation ranges from birth, with disorders of sexual development, through adolescent puber..

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