Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury
Paolo Calzavacca, Roger G Evans, Michael Bailey, Rinaldo Bellomo, Clive N May
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
OBJECTIVES: To determine whether there is a decrease in renal cortical or medullary perfusion and oxygenation in a conscious large animal model of hyperdynamic septic shock with acute kidney injury. DESIGN: Interventional animal study. SETTING: University-affiliated research institute. SUBJECTS: Eight merino ewes. INTERVENTIONS: Sheep were surgically instrumented with pulmonary and renal artery flow probes in the renal cortex and medulla, combination fiber-optic probes comprising a fluorescence optode to measure tissue PO2, and a laser-Doppler probe to assess tissue perfusion. Sepsis was induced by infusion of live Escherichia coli for 24 hours followed by 24-hour recovery. MEASUREMENTS AND ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Supported, in part, by a grant from the National Health and Medical Research Council of Australia (1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant.Dr. Calzavacca received support for article research from the Melbourne University overseas students' scholarship. Dr. Calzavacca was supported by an International Postgraduate Student Scholarship from the University of Melbourne. Dr. Evans is employed by Monash University, received support for travel from the American Physiological Society, and received support for article research from the National Health and Medical Research Council (NHMRC) of Australia. His institution received grant support from the Australian Research Council and from the NHMRC of Australia. Dr. May is employed by the Florey Institute of Neuroscience and lectured (honoraria and travel support for presentations from Medtronic) and received support for article research from the NHMRC. His institution received grant support from the NHMRC of Australia. The remaining authors have disclosed that they do not have any potential conflicts of interest.