Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt; D Buckley; J-MB Pang; J Panimaya; PJ Paul; C Gamell; EA Takano; Y Ying Lee; S Hiddingh; T-M Rogers; AFAS Teunisse; MJ Herold; J-C Marine; SB Fox; A Jochemsen; Y Haupt

Journal article

Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, J-MB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, T-M Rogers, AFAS Teunisse, MJ Herold, J-C Marine, SB Fox, A Jochemsen, Y Haupt

CELL DEATH & DISEASE | NATURE PUBLISHING GROUP | Published : 2015

DOI: 10.1038/cddis.2015.173

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Abstract

The function of the tumor suppressor p53 is universally compromised in cancers. It is the most frequently mutated gene in human cancers (reviewed). In cases where p53 is not mutated, alternative regulatory pathways inactivate its tumor suppressive functions. This is primarily achieved through elevation in the expression of the key inhibitors of p53: Mdm2 or Mdmx (also called Mdm4) (reviewed). In breast cancer (BrCa), the frequency of p53 mutations varies markedly between the different subtypes, with basal-like BrCas bearing a high frequency of p53 mutations, whereas luminal BrCas generally express wild-type (wt) p53. Here we show that Mdmx is unexpectedly highly expressed in normal breast ep..

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University of Melbourne Researchers

Susan Haupt Author Clinical Pathology

Marco Herold Author Medical Biology (w.e.h.i.)

Stephen Fox Author The Sir Peter Maccallum Department of Oncology

Ygal Haupt Author The Sir Peter Maccallum Department of Oncology

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Grants

Awarded by NHMRC

Awarded by CCV grant

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by NHMRC project grants (1026990, 1026988, 1049179 and 1063389) and NHMRC Fellowship to YH (9628426), by the CCV grant (1085154) and by the CASS Foundation. MJH was supported by an NHMRC project grant (APP1049720).