Electrophysiological characterization of spontaneous recovery in deep dorsal horn interneurons after incomplete spinal cord injury
MM Rank, JR Flynn, MP Galea, R Callister, RJ Callister
EXPERIMENTAL NEUROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
In the weeks and months following an incomplete spinal cord injury (SCI) significant spontaneous recovery of function occurs in the absence of any applied therapeutic intervention. The anatomical correlates of this spontaneous plasticity are well characterized, however, the functional changes that occur in spinal cord interneurons after injury are poorly understood. Here we use a T10 hemisection model of SCI in adult mice (9-10 wks old) combined with whole-cell patch clamp electrophysiology and a horizontal spinal cord slice preparation to examine changes in intrinsic membrane and synaptic properties of deep dorsal horn (DDH) interneurons. We made these measurements during short-term (4 wks)..View full abstract
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Awarded by NHMRC grant
This work was supported by NHMRC grant 628765. The authors thank Dr Melissa Tadros for assistance with manuscript editing and Mrs Lynda R Dunn for her technical support and outstanding animal husbandry expertise.