Journal article

Application of wMelPop Wolbachia Strain to Crash Local Populations of Aedes aegypti

Scott A Ritchie, Michael Townsend, Chris J Paton, Ashley G Callahan, Ary A Hoffmann

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2015


The endosymbiotic bacteria Wolbachia pipientis (wMel strain) has been successfully established in several populations of Aedes aegypti, the primary dengue vector. The virulent Wolbachia strain wMelPop is known to cause several pathological impacts (increased egg mortality, life shortening, etc.) reducing overall fitness in the mosquito Ae. aegypti. Increased egg mortality could substantially reduce egg banks in areas with a lengthy monsoonal dry season, and be employed to eliminate local populations. We tested this application under semi-field cage conditions. First, we determined that wMelPop infection significantly reduced the survival of desiccation-resistant eggs of the dengue vector Ae...

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University of Melbourne Researchers


Awarded by Australian Research Council

Awarded by National Health Medical Research Council

Funding Acknowledgements

The work was funded by Australian Research Council Laureate Fellowship - FL100100066, National Health Medical Research Council - 1037003 and Senior Research Fellowship 1044698 ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.