Journal article

Flow Chemistry: Intelligent Processing of Gas-Liquid Transformations Using a Tube-in-Tube Reactor

Martin Brzozowski, Matthew O'Brien, Steven V Ley, Anastasios Polyzos

ACCOUNTS OF CHEMICAL RESEARCH | AMER CHEMICAL SOC | Published : 2015

Abstract

CONSPECTUS: The previous decade has witnessed the expeditious uptake of flow chemistry techniques in modern synthesis laboratories, and flow-based chemistry is poised to significantly impact our approach to chemical preparation. The advantages of moving from classical batch synthesis to flow mode, in order to address the limitations of traditional approaches, particularly within the context of organic synthesis are now well established. Flow chemistry methodology has led to measurable improvements in safety and reduced energy consumption and has enabled the expansion of available reaction conditions. Contributions from our own laboratories have focused on the establishment of flow chemistry ..

View full abstract

Grants

Awarded by EPSRC


Awarded by Engineering and Physical Sciences Research Council


Funding Acknowledgements

The authors thank the following for financial support: CSIRO Manufacturing Flagship (M.B.), Sanofi-Aventis, CSIRO Julius Fellowship (A.P.), Engineering and Physical Sciences Research Council (EPSRC) (M.O.), and the BP 1702 Professorship (S.V.L.).