Journal article

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

Ulrike Gross, Peter Koos, Matthew O'Brien, Anastasios Polyzos, Steven V Ley

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | WILEY-V C H VERLAG GMBH | Published : 2014

Abstract

A series of continuous flow chemistry processes that facilitate the palladium-catalysed carbonylation of aryl and vinyl iodides and aryl bromides with a range of alkoxy, hydroxy and amino nucleophiles is reported. Harnessing a semipermeable Teflon® AF-2400 Tube-in-Tube assembly, these reactors permit the controlled transport of carbon monoxide into solution at elevated pressure to generate homogeneous flow streams, avoiding some potential issues associated with segmented flow gas-liquid reactors. As the volume of pressurised gas contained within the device is low, the hazards associated with this are potentially mitigated relative to comparable batch processes. We also show how the incorpora..

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University of Melbourne Researchers

Grants


Awarded by Engineering and Physical Sciences Research Council


Funding Acknowledgements

The authors thank the following for financial support: Georganics Ltd. (grant to P. K.), the German Academic Exchange Service (DAAD) (grant to U. G.), Sanofi-Aventis, CSIRO Material Science and Engineering, Clayton, Australia (grant to A. P.), Engineering and Physical Sciences Research Council (EPSRC) (grant to M. O.'B) and the BP 1702 Endowment (grant to S. V. L.).