Journal article
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley
Beilstein Journal of Organic Chemistry | Published : 2011
DOI: 10.3762/bjoc.7.194
Open access
Abstract
Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processi to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line pu fication. © 2011 Roper et al; licensee Beilstein-Institut.
Grants
Awarded by Engineering and Physical Sciences Research Council
Funding Acknowledgements
We thank GlaxoSmithKline (Stevenage) for studentship support (KAR), the Alexander von Humboldt Foundation (HL), the EPSRC (KAR & TP), the Royal Society University Research Fellowship (IRB) and the BP 1702 Fellowship (SVL) for financial support. We gratefully acknowledge Hokko Chemical Industry Co., Ltd. for their kind donation of diphenyl(4-vinyl-phenyl) phosphine).