The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
Kimberley A Roper, Heiko Lange, Anastasios Polyzos, Malcolm B Berry, Ian R Baxendale, Steven V Ley
Beilstein Journal of Organic Chemistry | BEILSTEIN-INSTITUT | Published : 2011
Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.
Awarded by Engineering and Physical Sciences Research Council
We thank GlaxoSmithKline (Stevenage) for studentship support (KAR), the Alexander von Humboldt Foundation (HL), the EPSRC (KAR & TP), the Royal Society University Research Fellowship (IRB) and the BP 1702 Fellowship (SVL) for financial support. We gratefully acknowledge Hokko Chemical Industry Co., Ltd. for their kind donation of diphenyl(4-vinyl-phenyl) phosphine).