Journal article

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A Roper, Heiko Lange, Anastasios Polyzos, Malcolm B Berry, Ian R Baxendale, Steven V Ley

Beilstein Journal of Organic Chemistry | BEILSTEIN-INSTITUT | Published : 2011


Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

University of Melbourne Researchers


Awarded by Engineering and Physical Sciences Research Council

Funding Acknowledgements

We thank GlaxoSmithKline (Stevenage) for studentship support (KAR), the Alexander von Humboldt Foundation (HL), the EPSRC (KAR & TP), the Royal Society University Research Fellowship (IRB) and the BP 1702 Fellowship (SVL) for financial support. We gratefully acknowledge Hokko Chemical Industry Co., Ltd. for their kind donation of diphenyl(4-vinyl-phenyl) phosphine).