Neuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial
K Leslie, D McIlroy, J Kasza, A Forbes, A Kurz, J Khan, CS Meyhoff, R Allard, G Landoni, X Jara, G Lurati Buse, K Candiotti, H-S Lee, R Gupta, T VanHelder, W Purayil, S De Hert, T Treschan, PJ Devereaux
BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2016
BACKGROUND: We assessed associations between intraoperative neuraxial block and postoperative epidural analgesia, and a composite primary outcome of death or non-fatal myocardial infarction, at 30 days post-randomization in POISE-2 Trial subjects. METHODS: 10 010 high-risk noncardiac surgical patients were randomized aspirin or placebo and clonidine or placebo. Neuraxial block was defined as intraoperative spinal anaesthesia, or thoracic or lumbar epidural anaesthesia. Postoperative epidural analgesia was defined as postoperative epidural local anaesthetic and/or opioid administration. We used logistic regression with weighting using estimated propensity scores. RESULTS: Neuraxial block was ..View full abstract
Awarded by Commonwealth Government of Australia's National Health and Medical Research Council
Canadian Institutes of Health Research, the Commonwealth Government of Australia's National Health and Medical Research Council (APP1004149) and the Spanish Ministry of Health and Social Policy.