BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila
Karen Doggett, Nezaket Turkel, Lee F Willoughby, Jason Ellul, Michael J Murray, Helena E Richardson, Anthony M Brumby
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endow tumor cells with cancer stem cell properties. To gain a greater understanding of how these properties are interlinked in cancers we used Drosophila epithelial tumor models, which are driven by orthologues of human oncogenes (activated alleles of Ras and Notch) in cooperation with the loss of the cell polarity regulator, scribbled (scrib). Within these tumors, both invasive, mesenchymal-like cell morphology and continual tumor overgrowth, are dependent upon Jun N-terminal kinase (JNK) activity. To identify JNK-dependent changes within the tumors we used a compara..View full abstract
Related Projects (1)
Awarded by National Health and Medical Research Council Australia
This work was supported by grants from the National Health and Medical Research Council Australia #509051 to AMB and #400211 to HER and AMB, and Peter MacCallum Internal funds to HER. HER is supported by a Senior Research Fellowship from the National Health and Medical Research Council Australia.