Effects of Asenapine in Bipolar I Patients Meeting Proxy Criteria for Moderate-to-Severe Mixed Major Depressive Episodes: A Post Hoc Analysis
Michael Berk, John WG Tiller, Jun Zhao, Lakshmi N Yatham, Gin S Malhi, Emmanuelle Weiller
JOURNAL OF CLINICAL PSYCHIATRY | PHYSICIANS POSTGRADUATE PRESS | Published : 2015
OBJECTIVE: Depression is the predominant psychosocial and suicide burden in bipolar disorder, yet there is a paucity of evidence-based treatments for bipolar depression. METHODS: This post hoc subgroup analysis of data pooled from two 3-week, randomized, placebo- and olanzapine-controlled trials (December 2004-April 2006, N = 489 and November 2004-April 2006, N = 488) examined a subgroup of patients meeting criteria for moderate-to-severe mixed major depressive episodes, defined using DSM-IV-TR criteria for mixed episodes (mania and major depression simultaneously) with a baseline Montgomery-Asberg Depression Rating Scale (MADRS) total score ≥ 20. RESULTS: Decreases in MADRS scores (least sq..View full abstract
H. Lundbeck A/S provided statistical support and funded the medical writing support by CHC Group.