Journal article

Quantitative Assessment of Intra-Patient Variation in CD4 T Cell Counts in Stable, Virologically-Suppressed, HIV-Infected Subjects

Claire L Gordon, Allen C Cheng, Paul U Cameron, Michael Bailey, Suzanne M Crowe, John Mills

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

OBJECTIVES: Counts of absolute CD4+ T lymphocytes (CD4+ T cells) are known to be highly variable in untreated HIV-infected individuals, but there are no data in virologically-suppressed individuals. We investigated CD4+ T cell variability in stable, virologically-suppressed, HIV-1 infected adults on combination antiretroviral therapy (cART). METHODS: From a large hospital database we selected patients with stable virological suppression on cART for >3 years with >10 CD4+ T cell measurements performed over a further >2 years; and a control group of 95 patients not on cART. RESULTS: We identified 161 HIV-infected patients on cART without active HCV or HBV infection, with stable virological sup..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

SMC is the recipient of an Australian National Health & Medical Research Council (NH&MRC) Principal Research Fellowship, and ACC is supported by an NH&MRC Career Development Fellowship. SMC, ACC, PUC, CLG and JM are or were employees of The Alfred Hospital. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.