Journal article

Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

CM Ortner, B Combrinck, S Allie, D Story, R Landau, K Cain, RA Dyer

BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2015

Abstract

BACKGROUND: The influence of common disturbances seen in preeclampsia, such as changes in strong ions and weak acids (particularly albumin) on acid-base status, has not been fully elucidated. The aims of this study were to provide a comprehensive acid-base analysis in severe preeclampsia and to identify potential new biological predictors of disease severity. METHODS: Fifty women with severe preeclampsia, 25 healthy non-pregnant- and 46 healthy pregnant controls (26-40 weeks' gestation), were enrolled in this prospective case-control study. Acid-base analysis was performed by applying the physicochemical approach of Stewart and Gilfix. RESULTS: Mean [sd] base excess was similar in preeclampt..

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University of Melbourne Researchers