FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy
Devy Deliyanti, Yuan Zhang, Fay Khong, David R Berka, David I Stapleton, Darren J Kelly, Jennifer L Wilkinson-Berka
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
Diabetic retinopathy features inflammation as well as injury to glial cells and the microvasculature, which are influenced by hypertension and overactivity of the renin-angiotensin system. FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. However, the potential therapeutic utility of FT011 for diabetic retinopathy has not been evaluated. We hypothesized that FT011 would attenuate retinopathy in diabetic Ren-2 rats, which exhibit hypertension due to an overactive extra-renal renin-angiotensin system. Diabetic rats were studied for 8 and 32 weeks and received intravitreal injections of FT..View full abstract
National Health and Medical Research Council of Australia provided a Senior Research Fellowship to JWB. The study was partially supported by a Peggy and Lesley Cranbourne Foundation grant to DIS.