Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis
Louise Organ, Barbara Bacci, Emmanuel Koumoundouros, Garry Barcham, Marjorie Milne, Wayne Kimpton, Chrishan Samuel, Ken Snibson
BMC Pulmonary Medicine | BMC | Published : 2015
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-clinical animal models are currently largely limited to small animals which have a number of shortcomings. We have previously shown that fibrosis is induced in isolated sheep lung segments 14 days after bleomycin treatment. This study aimed to determine whether bleomycin-induced fibrosis and associated functional changes persisted over a seven-week period. METHODS: Two separate lung segments in nine sheep received two challenges two weeks apart of either, 3U bleomycin (BLM),..View full abstract
Awarded by National Health & Medical Research Council (NHMRC) of Australia
We thank Robin Geyer for assistance with animal management, handling and tissue collection at the end of the animal experiments. None of the authors had specific funding for this study. C. Samuel is supported by a National Health & Medical Research Council (NHMRC) of Australia Senior Research Fellowship (APP1041766).Chrishan Samuel is supported by a National Health & Medical Research Council (NHMRC) of Australia Senior Research Fellowship (APP1041766).