Journal article
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8 T cells that induce GVHD without antileukemic effects
KH Gartlan, KA Markey, A Varelias, MD Bunting, M Koyama, RD Kuns, NC Raffelt, SD Olver, KE Lineburg, M Cheong, BE Teal, M Lor, I Comerford, MWL Teng, MJ Smyth, J McCluskey, J Rossjohn, B Stockinger, GM Boyle, SW Lane Show all
Blood | Published : 2015
Abstract
IL-17-producing cells are important mediators of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). Here we demonstrate that a distinct CD8+ Tc17 population develops rapidly after SCT but fails to maintain lineage fidelity such that they are unrecognizable in the absence of a fate reporter. Tc17 differentiation is dependent on alloantigen presentation by host dendritic cells (DCs) together with IL-6. Tc17 cells express high levels of multiple prototypic lineage-defining transcription factors (eg, RORγt, T-bet) and cytokines (eg, IL-17A, IL-22, interferon-γ, granulocyte macrophage colony-stimulating factor, IL-13). Targeted depletion of Tc17 early after transpl..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by grants from the Rio Tinto Ride to Conquer Cancer, Leukemia Foundation of Australia and the National Health and Medical Research Council.