Regulation of ERK-MAPK signaling in human epidermis
J Cursons, J Gao, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EJ Crampin
BMC Systems Biology | BioMed Central | Published : 2015
The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells differentiate and traverse the thickness of the skin. The stage of differentiation is therefore reflected in the positions of cells within the tissue, providing a convenient axis along which to study the signaling events that occur in situ during keratinocyte terminal differentiation, over this extended two-week timescale. The canonical ERK-MAPK signaling cascade (Raf-1, MEK-1/2 and ERK-1/2) has been implicated in controlling diverse cellular behaviors, including proliferation and differentiation. While the molecular interactions involved in signal transduction throug..View full abstract
Awarded by New Economy Research Fund (NZ) grant for Advanced Skin Imaging
Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
JC received funding from the Tertiary Education Commission (NZ) Top Achiever Doctoral Scholarship. This project received funding through a New Economy Research Fund (NZ) grant for Advanced Skin Imaging (contract C08X0801). This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036).