Journal article

Effect of birth weight on life-course blood pressure levels among children born premature: the Cardiovascular Risk in Young Finns Study

Markus Juonala, Michael MH Cheung, Matthew A Sabin, David Burgner, Michael R Skilton, Mika Kahonen, Nina Hutri-Kahonen, Terho Lehtimaki, Antti Jula, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Paivi Tossavainen, Jorma SA Viikari, Costan G Magnussen, Olli T Raitakari

JOURNAL OF HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

OBJECTIVES: Both fetal growth restriction and prematurity have been associated with elevated blood pressure (BP). However, their combined effects on adult BP are unclear. METHODS: Our analyses were based on 1756 participants in the population-based Cardiovascular Risk in Young Finns Study who had information on birth weight and gestational age, together with longitudinal data on cardiovascular risk markers from age 3-18 years in 1980 to age 34-49 years in 2011. Three groups were defined by birth data: those born at term (term); those born preterm (-1 SD z score according to national sex and gestational week-stratified data) for gestational age (preterm appropriate birth weight for gestationa..

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Grants

Awarded by Academy of Finland


Awarded by National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship)


Awarded by National Health and Medical Research Council Career Development Fellowship


Awarded by National Health and Medical Research Council Health Professional Training Fellowship


Awarded by National Health and Medical Research Senior Research Fellowship


Awarded by National Heart Foundation Future Leader Fellowship


Funding Acknowledgements

Funding Sources: This study was financially supported by the Academy of Finland (grants 126925, 121584, 124282, 129378, 117797, and 41071), the Social Insurance Institution of Finland, the Turku University Foundation, Paavo Nurmi Foundation, Juho Vainio Foundation, Sigrid Juselius Foundation, Paulo Foundation, Maud Kuistila Foundation, Research funds from the Kuopio, Turku, and Tampere University Hospitals, the Finnish Foundation of Cardiovascular Research, the Finnish Medical Foundation, the Orion-Farmos Research Foundation, and the Finnish Cultural Foundation. C.G.M. holds a National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship, APP1037559). M.R.S. holds a National Health and Medical Research Council Career Development Fellowship (APP1004474). M.A.S. holds a National Health and Medical Research Council Health Professional Training Fellowship (APP1012201). D.B. holds a National Health and Medical Research Senior Research Fellowship (APP1064629) and National Heart Foundation Future Leader Fellowship (100369). The Heart Research Group at Murdoch Childrens Research Institute is supported by Big W and RCH 1000, RCH Foundation. Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The sponsors had no role in preparing the manuscript.