Journal article

Short-Term White Matter Alterations in Alzheimer's Disease Characterized by Diffusion Tensor Imaging

Sila Genc, Christopher E Steward, Charles B Malpas, Dennis Velakoulis, Terence J O'Brien, Patricia M Desmond

JOURNAL OF MAGNETIC RESONANCE IMAGING | WILEY | Published : 2016

Abstract

PURPOSE: To investigate whether there are any white matter changes in a 6-month follow-up of mild-moderate Alzheimer's patients using diffusion tensor imaging (DTI). MATERIALS AND METHODS: We recruited 18 mild-moderate Alzheimer's disease patients and they underwent magnetic resonance imaging (MRI) at recruitment and at 6-month follow-up. Diffusion MRI images were processed using DTI-ToolKit to create a population-based tensor template. This template was integrated with a voxel-wise and atlas-based analysis in FSL to determine the magnitude and location of change in diffusion metrics over the 6-month follow-up period. RESULTS: There were significant widespread changes in diffusion metrics ac..

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