Journal article

STatistically Assigned Response Criteria in Solid Tumors (STARCIST)

Thomas Bengtsson, Sandra M Sanabria-Bohorquez, Timothy J McCarthy, David S Binns, Rodney J Hicks, Alex J de Crespigny

CANCER IMAGING | BMC | Published : 2015


BACKGROUND: Several reproducibility studies have established good test-retest reliability of FDG-PET in various oncology settings. However, these studies are based on relatively short inter-scan periods of 1-3 days while, in contrast, response assessments based on FDG-PET in early phase drug trials are typically made over an interval of 2-3 weeks during the first treatment cycle. With focus on longer, on-treatment scan intervals, we develop a data-driven approach to calculate baseline-specific cutoff values to determine patient-level changes in glucose uptake that are unlikely to be explained by random variability. Our method takes into account the statistical nature of natural fluctuations ..

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