The microbiome of otitis media with effusion in Indigenous Australian children
Jake Jervis-Bardy, Geraint B Rogers, Peter S Morris, Heidi C Smith-Vaughan, Elizabeth Nosworthy, Lex EX Leong, Renee J Smith, Laura S Weyrich, Jacques De Haan, A Simon Carney, Amanda J Leach, Stephen O'Leary, Robyn L Marsh
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | ELSEVIER IRELAND LTD | Published : 2015
INTRODUCTION: Indigenous Australian children have a high prevalence of otitis media with effusion (OME) and associated conductive hearing loss. Only three microbiological studies of middle ear fluid (MEF) from Indigenous Australian children with OME have been reported. All of these were reliant on culture or species-specific PCR assays. The aim of this study was to characterise the middle ear fluid (MEF), adenoid and nasopharyngeal (NP) microbiomes of Indigenous Australian children, using culture-independent 16S rRNA gene sequencing. METHODS: MEF, NP swabs and adenoid specimens were collected from 11 children in the Alice Springs region of Central Australia. Bacterial communities in these sp..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by National Health and Medical Research Council of Australia Centre for Research Excellence)
This study was supported by the National Health and Medical Research Council of Australia (Project Grant 1007641; Fellowships 1024175 to HCSV, 1020561 to AJL, 1034703 to RLM; and the Centre for Research Excellence Grant 1078557).