An EG-VEGF-Dependent Decrease in Homeobox Gene NKX3.1 Contributes to Cytotrophoblast Dysfunction: A Possible Mechanism in Human Fetal Growth Restriction
Padma Murthi, Sophie Brouillet, Anita Pratt, Anthony Borg, Bill Kalionis, Frederic Goffin, Vassilis Tsatsaris, Carine Munaut, Jean-Jacques Feige, Mohamed Benharouga, Thierry Fournier, Nadia Alfaidy
MOLECULAR MEDICINE | SPRINGER | Published : 2015
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Awarded by Australian National Health and Medical Research Council (NHMRC New Investigator project) award
The authors wish to thank the consenting patients and the clinical and research midwives at the Pregnancy Research Centre, Department of Perinatal Medicine, The Royal Women's Hospital for the supply of FGR and gestation-matched control placental tissues. INSERM (U1036), University Joseph Fourier, Commissariat a L'Energie Atomique (DSV/iRTSV/BCI). Funding support was provided from Groupement des Entreprises Francaises pour la Lutte contre le Cancer Comite Isere to N Alfaidy. Funding support for this work was provided from the Australian National Health and Medical Research Council (NHMRC New Investigator project grant #509140) award to P Murthi. We also thank F Balboni and QY Zhou for their collaboration. The human placental trophoblast-derived choriocarcinoma BeWo cell line (B30 clone) was a kind gift from Stephen Rogerson, The University of Melbourne, Department of Medicine, the Royal Melbourne Hospital, Victoria, Australia. The HTR-8/SVneo cells were a kind gift from Charles Graham, Queens University, Canada.