Journal article

Increased COX-2 expression in epithelial and stromal cells of high mammographic density tissues and in a xenograft model of mammographic density

GL Chew, CW Huo, D Huang, P Hill, J Cawson, H Frazer, JL Hopper, I Haviv, MA Henderson, K Britt, EW Thompson



Mammographic density (MD) adjusted for age and body mass index is one of the strongest known risk factors for breast cancer. Given the high attributable risk of MD for breast cancer, chemoprevention with a safe and available agent that reduces MD and breast cancer risk would be beneficial. Cox-2 has been implicated in MD-related breast cancer risk, and was increased in stromal cells in high MD tissues in one study. Our study assessed differential Cox-2 expression in epithelial and stromal cells in paired samples of high and low MD human breast tissue, and in a validated xenograft biochamber model of MD. We also examined the effects of endocrine treatment upon Cox-2 expression in high and low..

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Awarded by National Breast Cancer Foundation

Funding Acknowledgements

This work was supported by the Victorian Breast Cancer Research Consortium (EWT, JH), the St Vincent's Hospital Research Endowment Fund (EWT, GLC), the National Health and Medical Research Council (GLC, JH) and the University of Melbourne Research Grant Support Scheme (EWT, IH, GLC). This study benefited from support by the Victorian Government's Operational Infrastructure Support Program to St. Vincent's Institute.