Genomic risk prediction of complex human disease and its clinical application
Gad Abraham, Michael Inouye
CURRENT OPINION IN GENETICS & DEVELOPMENT | CURRENT BIOLOGY LTD | Published : 2015
Recent advances in genome-wide association studies have stimulated interest in the genomic prediction of disease risk, potentially enabling individual-level risk estimates for early intervention and improved diagnostic procedures. Here, we review recent findings and approaches to genomic prediction model construction and performance, then contrast the potential benefits of such models in two complex human diseases, aiding diagnosis in celiac disease and prospective risk prediction for cardiovascular disease. Early indications are that optimal application of genomic risk scores will differ substantially for each disease depending on underlying genetic architecture as well as current clinical ..View full abstract
Awarded by Australian NHMRC
Awarded by Heart Foundation
Awarded by NHMRC Peter Doherty Early Career Fellowship
We acknowledge support and funding from Australian NHMRC grant no. 1062227. MI was supported by a Career Development Fellowship co-funded by the NHMRC and Heart Foundation (no. 1061435). GA was supported by an NHMRC Peter Doherty Early Career Fellowship (no. 1090462).