Journal article
Loss of heterozygosity: What is it good for?
GL Ryland, MA Doyle, D Goode, SE Boyle, DYH Choong, SM Rowley, J Li, DD Bowtell, RW Tothill, IG Campbell, KL Gorringe
BMC Medical Genomics | Published : 2015
Abstract
Background: Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour suppressor gene through loss of the wild type allele. Methods: We analysed 86 ovarian carcinomas for mutations in 980 genes selected on the basis of their location in common regions of LOH. Results: We identified 36 significantly mutated genes, but these could only partly account for the quanta of LOH in the samples. Using our own and TCGA data we then evaluated five possible models to explain the se..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We gratefully acknowledge the cooperation of the institutions in Australia participating in the Australian Ovarian Cancer Study (AOCS). We also acknowledge the contribution of the AOCS study nurses, research assistants and all clinical and scientific collaborators and would like to thank all of the women who participated in AOCS. The AOCS management group comprises David Bowtell (Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia), Georgia Chenevix-Trench (Queensland Institute of Medical Research, Brisbane, Queensland, Australia), Adele Green (Queensland Institute of Medical Research, Brisbane, Queensland, Australia), Penny Webb (Queensland Institute of Medical Research, Brisbane, Queensland, Australia), Anna deFazio (Westmead lnstitute for Cancer Research, Westmead Millennium Institute, Westmead, New South Wales, Australia), Dorota Gertig (Victorian Cervical Cytology Registry, Carlton South, Victoria, Australia. The scientific and clinical collaborators are: ACT-R Stuart-Harris; NSW-F Kirsten, J Rutovitz, P Clingan, A Glasgow, A Proietto, S Braye, G Otton, J Shannon, T Bonaventura, J Stewart, S Begbie, M Friedlander, D Bell, S Baron-Hay, A Ferrier (dec.), G Gard, D Nevell, N Pavlakis, S Valmadre, B Young, C Camaris, R Crouch, L Edwards, N Hacker, D Marsden, G Robertson, P Beale, J Beith, J Carter, C Dalrymple, R Houghton, P Russell, L Anderson, M Links, J Grygiel, J Hill, A Brand, K Byth, R Jaworski, P Harnett, R Sharma, G Wain; QLD-D Purdie, D Whiteman, B Ward, D Papadimos, A Crandon, M Cummings, K Horwood. A Obermair, L Perrin, D Wyld, J Nicklin; SA-M Davy, MK Oehler, C Hall, T Dodd, T Healy, K Pittman, D Henderson, J Miller, J Pierdes, A Achan; TAS-P Blomfield, D Challis, R McIntosh, A Parker; VIC-B Brown, R Rome, D Allen, P Grant, S Hyde, R Laurie M Robbie, D Healy, T Jobling, T Manolitsas, J McNealage, P Rogers, B Susil, E Sumithran, I Simpson, I Haviv, K Phillips, D Rischin, S Fox, D Johnson, S Lade, P Waring, M Loughrey, N O'Callaghan, B Murray, L Mileshkin, P Allan; V Billson, J Pyman, D Neesham, M Quinn, A Hamilton, O McNally, C Underhill, R Bell, LF Ng, R Blum, V Ganju; WA-I Hammond, A McCartney (dec.), C Stewart, Y Leung, M Buck, N Zeps (WARTN). Further information can be found at http://www.aocstudy.org. This work was supported by the National Health and Medical Research Council of Australia (NHMRC ID #628773) and the Emer Casey Foundation.